Truncal Adiposity, Relative Growth Hormone Deficiency, and Cardiovascular Risk

Peripheral adiposity and cardiovascular risk.

To the Editor: In their recent Circulation article describing a study of older Danish women, Tankó et al1 presented strong evidence that peripheral localization of fat mass is associated with reduced calcification in the aorta. This interesting finding leads one to ask whether all anatomic sites of peripheral fat contribute equally to the apparent protective effect. Several studies have previou...

Effects of growth hormone replacement within the KIMS survey on estimated cardiovascular risk and predictors of risk reduction in patients with growth hormone deficiency.

OBJECTIVE There is growing evidence for an increased cardiovascular (CV) risk in untreated growth hormone deficiency of adults (GHD). We aimed at estimating CV risk with established algorithms before and during GH replacement in GHD and in healthy controls and at identifying predictors of risk reduction. DESIGN A prospective, nested case-control study. PATIENTS We included 344 patients (44·...

Adult Growth Hormone Deficiency

Adult growth hormone deficiency (AGHD) is an heterogeneous clinical entity characterized by increased cardiovascular morbidity and mortality, alterations in body composition, osteoporosis and impaired quality of life. In order to characterize higher risk subpopulations we studied 77 patients with AGHD, 35 with childhood onset (AGHD-CO): CA 18-44 yr.; 13 females and 22 males, and 42 with adult o...

Adult growth hormone deficiency.

Growth hormone (GH) has an important physiological role in adulthood.1–3 Before the 1980s anecdotal reports suggested that patients lacking GH experienced symptoms of increased fatigue and low mood, features that improved with GH replacement.4 Long-term replacement was not considered because of the lack of availability of cadaveric GH. With the development of recombinant GH in the mid-1980s, in...

Diagnosis of Growth Hormone Deficiency and Growth Hormone Stimulation Tests